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The present work was conducted to study the effect of ibuprofen (IBU) on histological parameters of male rats' liver for 30 and 60 days following oral administration. Fifty albino male rats are used in this study and they divided into five treatments each including five rats as control group, group administrated with 10mg/kg/day, group administrated with 20mg/kg/day, group administrated with 30mg/kg/day and group administrated with 40mg/kg/day of ibuprofen. The male rats were randomly divided into two main groups, comprising twenty-five rats for each group. The first main group was treated for 30 days and the second main group for 60 days. The animals were treated for 30 and 60 days following oral administration of 10, 20, 30, and 40mg/kg/day. The histological sections of the liver of the treatments at doses of 10, 20, 30, and 40mg/kg/day for 30 and 60 days showed high histopathological changes and their severity had raised by increasing concentration and exposure time.


Drug Histology NSAID Anti-inflammatory

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HADI, W. H., & ABOOD, A. H. (2022). Effect of ibuprofen on histological parameters of the liver in male albino rats. Iranian Journal of Ichthyology, 9, 234–240. Retrieved from


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