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This study was conducted to investigate the effect of the alcoholic and nano-extract of red radish (Raphanus sativua) on the function of the liver and kidneys in rats that had experimentally induced jaundice. Forty-eight white rats were divided into six groups: the control group dosed with physiological solution (0.9% Nacl), the T1 in which jaundice was induced, T2, the group of animals that treated with 200mg/kg of plant extract, T3, the group that dosed the nanocomposite of the plant extract at a dose of 200mg/kg daily, T4, the group that jaundice was induced and dosed with the normal extract of the plant, T5, the group that jaundice was developed and the plant extract nanocomposite was dosed at a dose of 200mg/kg daily. After the 21-day experiment, the animals were sacrificed, and the measurements were performed on the liver and kidney. The results showed that the induced of jaundice in the T1 caused a significant (P<0.05) decrease in the average weight of the liver and kidney, while there was a significant increase Liverl enzyme (ALK, LST, AST, urea and creatinine concentrations). The results also showed that the treatment of rats with hyperbilirubinemia with radish leaf extract group (T2) led to a significant (P<0.05) increase in liver and kidney weight and a significant decrease in liver enzymes (ALK, ALT, and AST,) and urea and creatinine concentration, compared with the T1. In the group treated with the red radish leaf nano-extract, the results showed improvements in the studied parameters. The histopathological changes were as hemorrhage, necrosis, rupture of liver tissue, glomerular atrophy, necrosis, disintegration and some inflammatory cells in the kidney tissue. It was concluded that the red radish leaf nanocomposite effectively improves the negative changes associated with hyperbilirubinemia.


Nano-extract Red radish Liver Kidney Rats Jaundice

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DHAHIR, M. R., & AL-NAELY, A. J. (2022). Effect of alcoholic and nano-extract of red radish, Raphanus sativua on liver and kidney function in rats induced jaundiced. Iranian Journal of Ichthyology, 9, 148–160. Retrieved from


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